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A phase 1/2 dose-escalation study to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of SN38-SPL9111 (DEP-SN38), a SN38 dendrimer conjugate, in patients with advanced solid tumours

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Trial Profile

A phase 1/2 dose-escalation study to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of SN38-SPL9111 (DEP-SN38), a SN38 dendrimer conjugate, in patients with advanced solid tumours

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 11 Jul 2024

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At a glance

  • Drugs Fluorouracil (Primary) ; Folinic acid (Primary) ; Irinotecan (Primary)
  • Indications Advanced breast cancer; Colorectal cancer; Gastrointestinal cancer; Ovarian cancer; Pancreatic cancer; Solid tumours
  • Focus Adverse reactions; First in man
  • Sponsors Starpharma

    • Most Recent Events

    • 04 Jun 2024 Results (n=114) assessing safety, tolerability and efficacy of DEP SN38 in pts with advanced solid tumors, including colorectal (CRC), platinum-resistant high-grade serous ovarian (HGSOC) and breast (BC) were presented at the 60th Annual Meeting of the American Society of Clinical Oncology
    • 26 Oct 2023 According to a Starpharma media release, recent results from this study will be presented at the Wilsons Drug and Device Conference tomorrow, 27 October 2023, at 10:00 AM AEST.
    • 13 Sep 2023 According to a Starpharma media release, this trial is being conducted at multiple sites, including Guy's Hospital in London, Beatson Cancer Centre in Glasgow, Imperial College London, and the Kinghorn Cancer Centre in Sydney.

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