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A Phase 3, External Placebo-Controlled, Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Patients With Neuromyelitis Optica Spectrum Disorder (NMOSD)

Trial Profile

A Phase 3, External Placebo-Controlled, Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Patients With Neuromyelitis Optica Spectrum Disorder (NMOSD)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 12 Dec 2025

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At a glance

  • Drugs Ravulizumab (Primary)
  • Indications Neuromyelitis optica
  • Focus Registrational; Therapeutic Use
  • Acronyms CHAMPION-NMOSD
  • Sponsors Alexion AstraZeneca Rare Disease

Most Recent Events

  • 06 Nov 2025 According to a AstraZeneca media release, based on results from this trial the company received approval form China's NMPA for Ultomiris for the treatment of adult patients with neuromyelitis optica spectrum disorder who are anti-aquaporin-4 antibody positive.
  • 19 Sep 2025 Results presented in a Alexion Antibody Technologies media release
  • 19 Sep 2025 According to a Alexion Antibody Technologies media release, Dr. Sean Pittock, MD, Mayo Clinic Glenn W. and Katherine K. Hasse Chair Neurology, is the principal investigator of this trial.

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