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An Open-Label Phase 1b Dose-Finding Trial Evaluating the Safety of Niraparib and Temozolomide and Atezolizumab in Participants With Advanced Solid Tumors and Expansion to a Phase 2 Trial Comparing the Effects of Niraparib and Temozolomide Plus Atezolizumab vs. Atezolizumab as Maintenance Therapy in Participants With Extensive-Stage Small Cell Lung Cancer With a Complete or Partial Response to Platinum-Based First-Line Chemotherapy (TRIO-US L-06)

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Trial Profile

An Open-Label Phase 1b Dose-Finding Trial Evaluating the Safety of Niraparib and Temozolomide and Atezolizumab in Participants With Advanced Solid Tumors and Expansion to a Phase 2 Trial Comparing the Effects of Niraparib and Temozolomide Plus Atezolizumab vs. Atezolizumab as Maintenance Therapy in Participants With Extensive-Stage Small Cell Lung Cancer With a Complete or Partial Response to Platinum-Based First-Line Chemotherapy (TRIO-US L-06)

Status: Suspended
Phase of Trial: Phase I/II

Latest Information Update: 28 Feb 2025

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At a glance

  • Drugs Niraparib (Primary) ; Temozolomide (Primary) ; Atezolizumab
  • Indications Small cell lung cancer; Solid tumours
  • Focus Adverse reactions; Therapeutic Use

Most Recent Events

  • 24 Feb 2025 Planned End Date changed from 3 Jan 2026 to 3 Jan 2027.
  • 24 Feb 2025 Planned primary completion date changed from 3 Jan 2025 to 3 Jan 2026.
  • 24 Feb 2025 Status changed from recruiting to suspended.

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