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A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate Pembrolizumab Versus Placebo as Adjuvant Therapy Following Surgery and Radiation in Participants With High-risk Locally Advanced Cutaneous Squamous Cell Carcinoma (LA cSCC) (KEYNOTE-630)

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Trial Profile

A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate Pembrolizumab Versus Placebo as Adjuvant Therapy Following Surgery and Radiation in Participants With High-risk Locally Advanced Cutaneous Squamous Cell Carcinoma (LA cSCC) (KEYNOTE-630)

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 02 Dec 2024

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At a glance

  • Drugs Pembrolizumab (Primary)
  • Indications Carcinoma; Skin cancer; Squamous cell cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms KEYNOTE-630
  • Sponsors Merck Sharp & Dohme; Merck Sharp & Dohme Corp.

Most Recent Events

  • 28 Nov 2024 Planned End Date changed from 29 Sep 2028 to 22 Dec 2025.
  • 15 Apr 2024 Status changed from recruiting to active, no longer recruiting.
  • 16 Nov 2023 Planned number of patients changed from 570 to 430.

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