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A Multicenter, Phase 1, Open-label, Dose-escalation and Expansion Study of TNB-383B, a Bispecific Antibody Targeting BCMA in Subjects With Relapsed or Refractory Multiple Myeloma

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Trial Profile

A Multicenter, Phase 1, Open-label, Dose-escalation and Expansion Study of TNB-383B, a Bispecific Antibody Targeting BCMA in Subjects With Relapsed or Refractory Multiple Myeloma

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 16 Jan 2025

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At a glance

  • Drugs TNB 383B (Primary)
  • Indications Multiple myeloma
  • Focus Adverse reactions; First in man; Pharmacodynamics; Pharmacokinetics
  • Sponsors Amgen; TeneoBio; TeneoOne

    • Most Recent Events

    • 04 Jun 2024 Results assessing Exposure-response analyses for optimal therapeutic dose selection of ABBV-383 in patients with relapsed/refractory multiple myeloma presented at the 60th Annual Meeting of the American Society of Clinical Oncology
    • 04 Jun 2024 Results assessing correlative biomarker analyses of baseline and longitudinal sBCMA levels and immune profiles, presented at the 60th Annual Meeting of the American Society of Clinical Oncology
    • 04 Jun 2024 Results assessing safety and efficacy that support the RP2D of 60mg Q4W as the optimal therapeutic ABBV-383 monotherapy dose, presented at the 60th Annual Meeting of the American Society of Clinical Oncology.

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