Trial Profile

A Phase 1b Biomarker-Driven Combination Trial of Copanlisib, Olaparib, and Durvalumab (MEDI4736) in Patients With Advanced Solid Tumors

Status: Active, no longer recruiting

Phase of Trial: Phase I

Latest Information Update: 24 Mar 2025

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At a glance

Drugs Copanlisib (Primary) ; Durvalumab (Primary) ; Olaparib (Primary)
Indications Advanced breast cancer; Appendiceal cancer; Colorectal cancer; Endometrial cancer; Gastric cancer; Head and neck cancer; Leiomyosarcoma; Ovarian cancer; Peritoneal cancer; Prostate cancer; Renal cancer; Solid tumours; Vulvovaginal cancer
Focus Adverse reactions

Most Recent Events

19 Mar 2025 Planned End Date changed from 31 Dec 2024 to 17 Mar 2026.
21 Dec 2023 Planned End Date changed from 1 Jun 2024 to 31 Dec 2024.
21 Dec 2023 Planned primary completion date changed from 1 Jun 2024 to 31 Dec 2024.

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