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A Randomized Phase I/II Trial in Patients With Newly Diagnosed, Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN) Evaluating a Mutanome-directed Immunotherapy

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Trial Profile

A Randomized Phase I/II Trial in Patients With Newly Diagnosed, Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN) Evaluating a Mutanome-directed Immunotherapy

Status: Active, no longer recruiting
Phase of Trial: Phase I/II

Latest Information Update: 23 Jun 2025

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At a glance

  • Drugs TG 4050 (Primary)
  • Indications Carcinoma; Head and neck cancer; Hypopharyngeal cancer; Laryngeal cancer; Mouth neoplasm; Oropharyngeal cancer; Squamous cell cancer
  • Focus Adverse reactions; First in man; Proof of concept; Therapeutic Use
  • Sponsors Transgene

Most Recent Events

  • 15 Jun 2025 Status changed from recruiting to active, no longer recruiting.
  • 02 Jun 2025 According to an Transgene media release, All patients are expected to be randomized by Q4 2025.
  • 02 Jun 2025 According to an Transgene media release, company presented new positive data on TG4050 in a rapid oral presentation at the American Society of Clinical Oncology (ASCO) Annual Meeting.

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