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A Phase 1, Randomized, Double-Blind, Placebo-Controlled Single Dose and Active Comparator-Controlled Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneously Administered ALN-AGT01 in Patients With Hypertension

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A Phase 1, Randomized, Double-Blind, Placebo-Controlled Single Dose and Active Comparator-Controlled Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneously Administered ALN-AGT01 in Patients With Hypertension

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 13 Oct 2023

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At a glance

  • Drugs Zilebesiran (Primary) ; Irbesartan
  • Indications Essential hypertension
  • Focus Adverse reactions; First in man
  • Sponsors Alnylam Pharmaceuticals

    • Most Recent Events

    • 10 Sep 2023 Results assessing the safety, pharmacodynamics, and efficacy of multiple dosing or administration of zilebesiran in patients with Class II/III obesity, presented at the Hypertension Scientific Session 2023.
    • 19 Jul 2023 Results presented in an Alnylam Pharmaceuticals Media Release.
    • 13 Jan 2023 Status changed from active, no longer recruiting to completed.

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