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A Phase 3 Randomized Study of Selumetinib Versus Carboplatin/Vincristine in Newly Diagnosed or Previously Untreated Neurofibromatosis Type 1 (NF1) Associated Low-Grade Glioma (LGG)

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Trial Profile

A Phase 3 Randomized Study of Selumetinib Versus Carboplatin/Vincristine in Newly Diagnosed or Previously Untreated Neurofibromatosis Type 1 (NF1) Associated Low-Grade Glioma (LGG)

Status: Recruiting
Phase of Trial: Phase III

Latest Information Update: 08 Jun 2025

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At a glance

  • Drugs Selumetinib (Primary) ; Carboplatin; Vincristine
  • Indications Glioma; Neurofibromatosis 1
  • Focus Therapeutic Use

Most Recent Events

  • 17 Apr 2025 Planned number of patients changed from 290 to 165.
  • 13 Feb 2025 Planned End Date changed from 1 May 2027 to 31 Dec 2030.
  • 13 Feb 2025 Planned primary completion date changed from 1 May 2027 to 31 Dec 2030.

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