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A Phase II Basket Trial of Glutaminase Inhibitor (BEGIN) Telaglenastat (CB-839) HCL in Patients With NF1 Aberrations, NF1 Mutant Malignant Peripheral Nerve Sheath Tumors (MPNST), KEAP1/NRF2 and LKB1 Aberrant Tumors

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Trial Profile

A Phase II Basket Trial of Glutaminase Inhibitor (BEGIN) Telaglenastat (CB-839) HCL in Patients With NF1 Aberrations, NF1 Mutant Malignant Peripheral Nerve Sheath Tumors (MPNST), KEAP1/NRF2 and LKB1 Aberrant Tumors

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 07 May 2025

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At a glance

  • Drugs Telaglenastat (Primary)
  • Indications Nerve sheath neoplasms; Solid tumours
  • Focus Therapeutic Use
  • Acronyms BeGIN

Most Recent Events

  • 27 Apr 2025 Planned End Date changed from 10 Apr 2026 to 16 Apr 2026.
  • 15 Apr 2025 Planned End Date changed from 31 Aug 2024 to 10 Apr 2026.
  • 01 Sep 2023 Planned End Date changed from 31 Aug 2023 to 31 Aug 2024.

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