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Ph 2, Multi-arm, Multicenter, Open-label Study to Evaluate Efficacy and Safety of IPI-549 Administered in Combo With Front-line Treatment Regimens in Pts With Locally Advanced and/or Metastatic Triple-Negative Breast Cancer or Renal Cell Carcinoma

Trial Profile

Ph 2, Multi-arm, Multicenter, Open-label Study to Evaluate Efficacy and Safety of IPI-549 Administered in Combo With Front-line Treatment Regimens in Pts With Locally Advanced and/or Metastatic Triple-Negative Breast Cancer or Renal Cell Carcinoma

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 17 Aug 2023

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At a glance

  • Drugs Atezolizumab (Primary) ; Bevacizumab (Primary) ; Eganelisib (Primary) ; Paclitaxel (Primary)
  • Indications Advanced breast cancer; Male breast cancer; Renal cell carcinoma; Triple negative breast cancer
  • Focus Therapeutic Use
  • Acronyms MARIO-3
  • Sponsors Infinity Pharmaceuticals
  • Most Recent Events

    • 08 Aug 2023 Planned End Date changed from 1 Aug 2022 to 31 Aug 2023.
    • 08 Aug 2023 Planned primary completion date changed from 1 Aug 2022 to 31 Aug 2023.
    • 13 Apr 2023 According to an Infinity Pharmaceuticals media release, translational data showing increased systemic immune activation in patients treated with nivolumab in combination with eganelisib over nivolumab alone, with enrichment of genes from interferon signaling, antigen presentation, and T cell receptor pathways will be presented at the 2023 Annual Meeting of the American Association of Cancer Research (AACR) to be held April 14 - 19, 2023 in Orlando, Florida.

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