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A Randomized, Phase 3, Open-Label Trial Comparing the Effect of LY3298176 Versus Titrated Insulin Degludec on Glycemic Control in Patients With Type 2 Diabetes

Trial Profile

A Randomized, Phase 3, Open-Label Trial Comparing the Effect of LY3298176 Versus Titrated Insulin Degludec on Glycemic Control in Patients With Type 2 Diabetes

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 23 May 2024

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At a glance

  • Drugs Tirzepatide (Primary) ; Insulin degludec
  • Indications Type 2 diabetes mellitus
  • Focus Registrational; Therapeutic Use
  • Acronyms SURPASS-3
  • Sponsors Eli Lilly and Company

Most Recent Events

  • 23 May 2024 Results describing the overall fat distribution patterns independent of body mass index (BMI) in participants with type 2 diabetes (T2D) in the SURPASS-3 MRI substudy by comparison with sex- and BMI-matched virtual control groups (VCGs) derived from the UK Biobank imaging study at baseline and Week 52, published in the Diabetes, Obesity and Metabolism
  • 10 Apr 2024 According to a AMRA Medical media release, an exploratory analysis published in Diabetes, Obesity and Metabolism using data from SURPASS-3 MRI study, shows significant reduction of both visceral- and liver fat z-scores, and a shift towards a more balanced fat distribution pattern with tirzepatide treatment.
  • 25 Jan 2024 Results assessing the evaluate gastrointestinal adverse events (AEs) and the impact of nausea, vomiting or diarrhoea (N/V/D) and any gastrointestinal (GI) AEs overall on weight change with tirzepatide from SURPASS 1-5 Trials, published in the Diabetes, Obesity and Metabolism

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