The TNT Protocol: A Phase 2 Study Using Talimogene Laherparepvec,Nivolumab and Trabectedin as First, Second/Third Line Therapy for Advanced Sarcoma, Including Desmoid Tumor and Chordoma
Latest Information Update: 28 Feb 2025
At a glance
- Drugs Nivolumab (Primary) ; Talimogene laherparepvec (Primary) ; Trabectedin (Primary)
- Indications Chordoma; Ewing's sarcoma; Fibroma; Leiomyosarcoma; Liposarcoma; Malignant fibrous histiocytoma; Sarcoma; Soft tissue sarcoma
- Focus Therapeutic Use
Most Recent Events
- 24 Feb 2025 Planned number of patients changed from 40 to 200.
- 24 Feb 2025 Planned End Date changed from 31 Mar 2025 to 31 Jul 2031.
- 24 Feb 2025 Planned primary completion date changed from 31 Dec 2024 to 31 Dec 2030.