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Phase 3 Study of Sacituzumab Govitecan (IMMU-132) Versus Treatment of Physician's Choice (TPC) in Subjects With Hormonal Receptor-Positive (HR+) Human Epidermal Growth Factor Receptor 2 (HER2) Negative Metastatic Breast Cancer (MBC) Who Have Failed at Least Two Prior Chemotherapy Regimens

Trial Profile

Phase 3 Study of Sacituzumab Govitecan (IMMU-132) Versus Treatment of Physician's Choice (TPC) in Subjects With Hormonal Receptor-Positive (HR+) Human Epidermal Growth Factor Receptor 2 (HER2) Negative Metastatic Breast Cancer (MBC) Who Have Failed at Least Two Prior Chemotherapy Regimens

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 20 Jun 2025

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At a glance

  • Drugs Sacituzumab govitecan (Primary) ; Capecitabine; Eribulin; Gemcitabine; Vinorelbine
  • Indications Advanced breast cancer; HER2 negative breast cancer; Male breast cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms TROPICS-02
  • Sponsors Gilead Sciences; Immunomedics

Most Recent Events

  • 30 Apr 2025 Results assessing specific mutations at BSL and EOT in TROPiCS-02 to identify genes that may be involved in acquired SG resistance, presented at the 116th Annual Meeting of the American Association for Cancer Research.
  • 06 Sep 2024 Results presenting health-related quality of life (HRQoL) patient-reported outcome (PRO) findings from this study published in the Oncologist
  • 04 Jun 2024 Results assessing comprehensive genomic analysis of DDR gene variants and impact on SG clinical efficacy in this patient population presented at the 60th Annual Meeting of the American Society of Clinical Oncology

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