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A Phase 2, Open-Label, Randomized, Multicenter Trial of Encorafenib + Binimetinib Evaluating a Standard-dose and a High-dose Regimen in Patients With BRAFV600-mutant Melanoma Brain Metastasis

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Trial Profile

A Phase 2, Open-Label, Randomized, Multicenter Trial of Encorafenib + Binimetinib Evaluating a Standard-dose and a High-dose Regimen in Patients With BRAFV600-mutant Melanoma Brain Metastasis

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 02 Jun 2023

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At a glance

  • Drugs Binimetinib (Primary) ; Encorafenib (Primary)
  • Indications Brain metastases; Malignant melanoma; Skin cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms POLARIS
  • Sponsors Array BioPharma; Pfizer

Most Recent Events

  • 18 Apr 2022 Status changed from completed to discontinued.
  • 07 Mar 2022 Status changed from active, no longer recruiting to completed.
  • 02 Jul 2021 Status changed from recruiting to active, no longer recruiting.

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