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A Phase III Randomized, Placebo-Controlled Study of Pembrolizumab (MK-3475, NSC 776864) in Addition to Paclitaxel and Carboplatin for Measurable Stage III or IVA, Stage IVB or Recurrent Endometrial Cancer

Trial Profile

A Phase III Randomized, Placebo-Controlled Study of Pembrolizumab (MK-3475, NSC 776864) in Addition to Paclitaxel and Carboplatin for Measurable Stage III or IVA, Stage IVB or Recurrent Endometrial Cancer

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 12 Jun 2025

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At a glance

  • Drugs Pembrolizumab (Primary) ; Carboplatin; Paclitaxel
  • Indications Adenocarcinoma; Endometrial cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms KEYNOTE-868

Most Recent Events

  • 06 Jun 2025 Planned End Date changed from 1 Apr 2029 to 8 May 2026.
  • 01 May 2025 Results of exploratory analysis assessing efficacy of pembrolizumab plus chemotherapy in advanced or recurrent endometrial cancer published in the Nature Medicine
  • 19 Mar 2025 According to Merck and Co media release, company announced that Health Canada approved KEYTRUDA for the treatment of adult patients with primary advanced or recurrent endometrial carcinoma.

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