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A Phase 1 Trial of the Safety, Tolerability and Biological Effects of Intravenous Enadenotucirev, a Novel Oncolytic Virus, in Combination With Chemoradiotherapy in Locally Advanced Rectal Cancer

Trial Profile

A Phase 1 Trial of the Safety, Tolerability and Biological Effects of Intravenous Enadenotucirev, a Novel Oncolytic Virus, in Combination With Chemoradiotherapy in Locally Advanced Rectal Cancer

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 10 Feb 2025

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At a glance

  • Drugs Capecitabine (Primary) ; Enadenotucirev (Primary)
  • Indications Adenocarcinoma; Colorectal cancer; Rectal cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms CEDAR
  • Sponsors Akamis Bio

Most Recent Events

  • 28 Feb 2024 Results assessing tolerability, persistence and pharmacodynamic (PD) profile of IV-administered next-generation adenoviral vectors supports clinical expansion in solid cancers presented at the ESMO Targeted Anticancer Therapies Congress 2024
  • 03 Oct 2023 Results presented in an Akamis Bio Media Release.
  • 03 Oct 2023 According to an Akamis Bio media release, data from this study will be Presented at the 2023 American Society for Radiation Oncology (ASTRO) Annual Meeting.

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