Trial Profile

An Open-label Study of ALPN-202 in Subjects With Advanced Malignancies (NEON-1)

Status: Discontinued

Phase of Trial: Phase I

Latest Information Update: 07 Jun 2023

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At a glance

Drugs Davoceticept (Primary)
Indications Carcinoma; Cholangiocarcinoma; Colorectal cancer; Lymphoma; Malignant melanoma; Mesothelioma; Pancreatic cancer; Renal cell carcinoma; Skin cancer; Solid tumours
Focus Adverse reactions; First in man
Acronyms NEON-1
Sponsors Alpine Immune Sciences

02 Jun 2023 Status changed from active, no longer recruiting to discontinued.
08 Nov 2022 Planned primary completion date changed from 1 Dec 2024 to 1 Dec 2022.
24 Oct 2022 According to an Alpine Immune Sciences media release, the company has voluntarily terminated enrollment in the NEON-1 and NEON-2 trials. The decision to terminate enrollment in the davoceticept studies was made in the interest of patient safety after the Company was notified of a second death in the NEON-2 study, attributed to cardiogenic shock.

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