A Phase 3, Randomized, Double-blind Study to Evaluate Perioperative Pembrolizumab (MK-3475) + Neoadjuvant Chemotherapy Versus Perioperative Placebo + Neoadjuvant Chemotherapy in Cisplatin-eligible Participants With Muscle-invasive Bladder Cancer (KEYNOTE-866)
Latest Information Update: 16 Jul 2026
At a glance
- Drugs Pembrolizumab (Primary) ; Cisplatin; Gemcitabine
- Indications Bladder cancer; Carcinoma; Urogenital cancer
- Focus Registrational; Therapeutic Use
- Acronyms KEYNOTE-866
- Sponsors Merck Sharp & Dohme; Merck Sharp & Dohme Corp.
Most Recent Events
- 28 May 2026 Status changed from active, no longer recruiting to completed.
- 28 Aug 2025 Planned primary completion date changed from 2 Sep 2025 to 26 Jan 2026.
- 24 Mar 2025 Planned End Date changed from 15 Jun 2025 to 1 Sep 2026.