Neoadjuvant PD-1 Blockade Toripalimab With or Without Celecoxib in Mismatch-repair Deficient or Microsatellite Instability-high Locally Advanced Colorectal Cancer (PICC): a Parallel-group, Randomized, Multi-cohort, Phase 2 Trial
Latest Information Update: 07 Jan 2025
At a glance
- Drugs Celecoxib (Primary) ; Toripalimab (Primary)
- Indications Adenocarcinoma; Colon cancer; Rectal cancer
- Focus Therapeutic Use
- Acronyms PICC
Most Recent Events
- 15 Jul 2024 Planned number of patients changed from 112 to 150.
- 18 Feb 2024 Phase changed from phase 1/2 to phase 2. Upper age limit of inclusion criteria is increased from 75 years to 100 years.
- 18 Feb 2024 Planned number of patients changed from 100 to 112.