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A Phase Ib Trial of Vaginal Cuff Brachytherapy + Pembrolizumab (MK3475) Followed by 3 Cycles of Dose Dense Paclitaxel/q 21 Day Carboplatin + Pembrolizumab (MK3475) in High Intermediate Risk Endometrial Cancer

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A Phase Ib Trial of Vaginal Cuff Brachytherapy + Pembrolizumab (MK3475) Followed by 3 Cycles of Dose Dense Paclitaxel/q 21 Day Carboplatin + Pembrolizumab (MK3475) in High Intermediate Risk Endometrial Cancer

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 20 Feb 2025

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At a glance

  • Drugs Carboplatin (Primary) ; Paclitaxel (Primary) ; Pembrolizumab (Primary)
  • Indications Carcinoma; Endometrial cancer
  • Focus Therapeutic Use
  • Acronyms FIERCE

    • Most Recent Events

    • 13 Feb 2025 Planned number of patients changed from 40 to 45.
    • 13 Feb 2025 Planned End Date changed from 1 Sep 2025 to 1 Feb 2026.
    • 13 Feb 2025 Planned primary completion date changed from 1 Dec 2024 to 1 Jun 2025.

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