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A Phase 1/2 Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of Sitravatinib as Monotherapy and in Combination With Tislelizumab in Patients With Unresectable Locally Advanced or Metastatic Hepatocellular Carcinoma or Gastric/Gastroesophageal Junction Cancer

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Trial Profile

A Phase 1/2 Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of Sitravatinib as Monotherapy and in Combination With Tislelizumab in Patients With Unresectable Locally Advanced or Metastatic Hepatocellular Carcinoma or Gastric/Gastroesophageal Junction Cancer

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 30 Oct 2024

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At a glance

  • Drugs Sitravatinib (Primary) ; Tislelizumab (Primary)
  • Indications Gastric cancer; Liver cancer; Oesophageal cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms SAFFRON-104
  • Sponsors BeiGene

    • Most Recent Events

    • 05 Sep 2024 Results (at data cutoff: 31 Ma 2023) reporting safety and preliminary clinical activity of sitravatinib published in the Cancer Immunology Immunotherapy
    • 24 Oct 2023 Results presented at the 48th European Society for Medical Oncology Congress.
    • 10 Apr 2023 Status changed from active, no longer recruiting to completed.

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