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An Open-Label Study in Adolescent and Adult Severe (Coagulation Factor Activity <1%) Hemophilia A Participants With or Without Inhibitors or Moderately Severe to Severe Hemophilia B Participants (Coagulation Factor Activity ≤2%) With or Without Inhibitors Comparing Standard Treatment to PF-06741086 Prophylaxis

Trial Profile

An Open-Label Study in Adolescent and Adult Severe (Coagulation Factor Activity <1%) Hemophilia A Participants With or Without Inhibitors or Moderately Severe to Severe Hemophilia B Participants (Coagulation Factor Activity ≤2%) With or Without Inhibitors Comparing Standard Treatment to PF-06741086 Prophylaxis

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 17 Jun 2025

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At a glance

  • Drugs Marstacimab (Primary)
  • Indications Haemophilia A; Haemophilia B
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms BASIS
  • Sponsors Pfizer

Most Recent Events

  • 27 Dec 2025 According to a Pfizer media release, based on the results of this global Phase 3 study (BASIS study) , company has received marketing approval in Japan for HIMPEBD Subcutaneous Injection 150 mg Pen for suppression of bleeding tendency in patients with congenital hemophilia without inhibitors to blood coagulation factor VIII or IX.
  • 10 Jun 2025 Status changed from active, no longer recruiting to completed.
  • 05 Dec 2024 According to a Pfizer media release, data from this trial to be presented at American Society of Hematology (ASH) Annual Meeting & Exposition (December 7-10) and the San Antonio Breast Cancer Symposium (SABCS, December 10-13).

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