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Randomized Phase 2 Trial of Cetuximab and Avelumab or Avelumab Alone for Unresectable, Locally Advanced or Metastatic Squamous Cell Anal Carcinoma (SCCAC) Progressed After at Least One Line of Systemic Treatment

Trial Profile

Randomized Phase 2 Trial of Cetuximab and Avelumab or Avelumab Alone for Unresectable, Locally Advanced or Metastatic Squamous Cell Anal Carcinoma (SCCAC) Progressed After at Least One Line of Systemic Treatment

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 13 Feb 2023

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At a glance

  • Drugs Avelumab (Primary) ; Cetuximab (Primary)
  • Indications Anal cancer; Carcinoma; Squamous cell cancer
  • Focus Therapeutic Use
  • Acronyms CARACAS

Most Recent Events

  • 09 Jan 2023 Results assessing Extensive molecular profiling of squamous cell anal carcinoma in a phase 2 trial population published in the European Journal of Cancer
  • 22 Jan 2022 Results presented at the 2022 Gastrointestinal Cancers Symposium
  • 21 Sep 2020 Primary endpoint (Primary endpoint is Objective Response Rate (ORR) (Arm B)) has been met as per results presented at the 45th European Society for Medical Oncology Congress.

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