Trial Profile

A Phase II Trial of Carboplatin, Paclitaxel, and Nivolumab Induction Therapy Followed by Response-stratified Locoregional Therapy for Patients With Locally Advanced, HPV-negative Head and Neck Cancer. The DEPEND Trial.

Status: Completed

Phase of Trial: Phase II

Latest Information Update: 20 May 2025

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At a glance

Drugs Carboplatin (Primary) ; Nivolumab (Primary) ; Paclitaxel (Primary) ; Cisplatin; Filgrastim; Fluorouracil; Hydroxycarbamide
Indications Head and neck cancer; Hypopharyngeal cancer; Laryngeal cancer; Mouth neoplasm; Nasopharyngeal cancer; Oropharyngeal cancer; Squamous cell cancer
Focus Therapeutic Use
Acronyms DEPEND

11 May 2025 Status changed from recruiting to completed.
14 Mar 2025 According to CEL-SCI Corporation media release, data from this this study published in the Journal of the American Medical Association (JAMA) Oncology on March 6, 2025.
15 Aug 2024 Planned End Date changed from 1 Jul 2024 to 1 Jul 2025.

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