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A Randomized, Placebo-Controlled, Double-Blind Study of Adjuvant Cemiplimab Versus Placebo After Surgery and Radiation Therapy in Patients With High Risk Cutaneous Squamous Cell Carcinoma

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Trial Profile

A Randomized, Placebo-Controlled, Double-Blind Study of Adjuvant Cemiplimab Versus Placebo After Surgery and Radiation Therapy in Patients With High Risk Cutaneous Squamous Cell Carcinoma

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 10 Jul 2026

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At a glance

  • Drugs Cemiplimab (Primary)
  • Indications Chronic lymphocytic leukaemia; Skin cancer; Squamous cell cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms C-POST
  • Sponsors Regeneron Pharmaceuticals

Most Recent Events

  • 27 Mar 2026 Planned End Date changed from 26 Mar 2028 to 7 Jan 2028.
  • 27 Mar 2026 Planned primary completion date changed from 3 Nov 2026 to 7 Jan 2028.
  • 17 Oct 2025 According to a Regeneron Pharmaceuticals media release, company announced that the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion for Libtayo (cemiplimab) as an adjuvant treatment for adult patients with cutaneous squamous cell carcinoma (CSCC) at high risk of recurrence after surgery and radiation. The European Commission is expected to make a final decision on the application in the coming months.

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