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A Phase Ib, Open-Label, Multicenter Study To Investigate The Pharmacokinetics, Safety, And Tolerability Of Subcutaneous Ocrelizumab Administration In Patients With Multiple Sclerosis

Trial Profile

A Phase Ib, Open-Label, Multicenter Study To Investigate The Pharmacokinetics, Safety, And Tolerability Of Subcutaneous Ocrelizumab Administration In Patients With Multiple Sclerosis

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 26 Mar 2025

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At a glance

  • Drugs Ocrelizumab (Primary) ; Ocrelizumab (Primary) ; Hyaluronidase
  • Indications Multiple sclerosis
  • Focus Adverse reactions; Pharmacokinetics
  • Acronyms Ocarina I
  • Sponsors Roche
  • Most Recent Events

    • 18 Apr 2024 Results assessing safety, tolerability and pharmacokinetic data in patients with relapsing and primary progressive multiple sclerosis (RMS/PPMS), to select the appropriate OCR subcutaneous (SC) dose for OCARINA II, were presented at the 76th Annual Meeting of the American Academy of Neurology 2024.
    • 17 Apr 2024 Planned primary completion date changed from 30 Jun 2023 to 20 Jun 2025.
    • 02 Mar 2024 Results assessing the OCR safety, tolerability and pharmacokinetics in patients with RMS/PPMS, to select the appropriate OCR SC dose for OCARINA II, presented at the Americas Committee for Treatment and Research in Multiple Sclerosis Forum 2024.

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