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An Open-Label, Multi-Centre Phase I/IIa Study Evaluating the Safety and Clinical Activity of Neoantigen Reactive T Cells in Patients With Advanced Non-Small Cell Lung Cancer

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Trial Profile

An Open-Label, Multi-Centre Phase I/IIa Study Evaluating the Safety and Clinical Activity of Neoantigen Reactive T Cells in Patients With Advanced Non-Small Cell Lung Cancer

Status: Discontinued
Phase of Trial: Phase I/II

Latest Information Update: 12 Mar 2025

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At a glance

  • Drugs ATL 001 (Primary) ; Pembrolizumab (Primary) ; Cyclophosphamide; Fludarabine; Interleukin-2
  • Indications Adenosquamous carcinoma; Non-small cell lung cancer
  • Focus Adverse reactions; First in man; Proof of concept
  • Acronyms ATX-NS-001; CHIRON
  • Sponsors Achilles Therapeutics

    • Most Recent Events

    • 10 Mar 2025 Time frame of primary endpoint changed from 84 months to 62 months due to early termination, hence the protocol was amended.
    • 19 Sep 2024 According to Achilles Therapeutics media release, full clinical data generated from the Phase I/IIa CHIRON trial in patients with advanced non-small cell lung cancer (NSCLC) will be presented in an upcoming forum.
    • 19 Sep 2024 According to Achilles Therapeutics media release, company today announced the discontinuation of its TIL-based cNeT program and closure of the Phase I/IIa CHIRON and THETIS clinical trials.

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