Trial Profile

A First-in-Human, Phase 1a/1b, Open Label, Dose-Escalation and Expansion Study to Investigate the Safety, Pharmacokinetics, and Antitumor Activity of the RAF Dimer Inhibitor BGB-3245 in Patients With Advanced or Refractory Tumors

Status: Active, no longer recruiting

Phase of Trial: Phase I

Latest Information Update: 10 Feb 2025

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At a glance

Drugs Brimarafenib (Primary)
Indications Colorectal cancer; Malignant melanoma; Non-small cell lung cancer; Pancreatic cancer; Solid tumours
Focus Adverse reactions; First in man; Therapeutic Use
Sponsors MapKure

07 Feb 2025 Planned End Date changed from 2 Jun 2025 to 1 Nov 2025.
07 Feb 2025 Planned primary completion date changed from 2 Jun 2025 to 1 Nov 2025.
07 Feb 2025 Status changed from recruiting to active, no longer recruiting.

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