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A Randomized, Double-Blind, Placebo-Controlled Phase III Clinical Trial of Pembrolizumab (MK-3475) in Combination With Cisplatin and 5-Fluorouracil Versus Placebo in Combination With Cisplatin and 5-Fluorouracil as First-Line Treatment in Subjects With Advanced/Metastatic Esophageal Carcinoma (KEYNOTE-590)

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A Randomized, Double-Blind, Placebo-Controlled Phase III Clinical Trial of Pembrolizumab (MK-3475) in Combination With Cisplatin and 5-Fluorouracil Versus Placebo in Combination With Cisplatin and 5-Fluorouracil as First-Line Treatment in Subjects With Advanced/Metastatic Esophageal Carcinoma (KEYNOTE-590)

Status: Withdrawn prior to enrolment
Phase of Trial: Phase III

Latest Information Update: 04 Nov 2021

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At a glance

  • Drugs Pembrolizumab (Primary) ; Cisplatin; Fluorouracil
  • Indications Adenocarcinoma; Carcinoma; Gastric cancer; Oesophageal cancer; Squamous cell cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms KEYNOTE590
  • Sponsors Merck Sharp & Dohme Corp.

    • Most Recent Events

    • 30 May 2021 This trial has been completed in Denmark, according to European Clinical Trials Database record.
    • 16 Apr 2021 Planned End Date changed from 11 May 2022 to 3 Jun 2022.
    • 07 Feb 2020 Status changed from active, no longer recruiting to withdrawn prior to enrolment.

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