Trial Profile

A Phase 1, Open-label Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of Oral EPI-7386 in Patients With Castration-Resistant Prostate Cancer

Status: Discontinued

Phase of Trial: Phase I

Latest Information Update: 05 Mar 2025

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At a glance

Drugs Abiraterone acetate (Primary) ; Apalutamide (Primary) ; Masofaniten (Primary) ; Prednisone (Primary)
Indications Prostate cancer
Focus Adverse reactions; First in man; Proof of concept; Therapeutic Use
Sponsors ESSA Pharma

12 Nov 2024 Planned End Date changed from 1 Sep 2026 to 1 Jan 2025.
31 Oct 2024 According to an ESSA Pharma media release, clinical studies with masofaniten including the combination study with abiraterone acetate and apalutamide as well as the remaining investigator sponsored trials will also be terminated and the IND and CTAs in different geographies will be withdrawn.
31 Oct 2024 According to an ESSA Pharma media release, status changed from recruiting to discontinued.

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