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Phase II Study of Short Course FOLFOX Chemotherapy With Either Nivolumab or Nivolumab + Radiation in the First Line Treatment of Metastatic or Unresectable Gastroesophageal Cancers (BMS Protocol CA209-76L)

Trial Profile

Phase II Study of Short Course FOLFOX Chemotherapy With Either Nivolumab or Nivolumab + Radiation in the First Line Treatment of Metastatic or Unresectable Gastroesophageal Cancers (BMS Protocol CA209-76L)

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 27 Jun 2025

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At a glance

  • Drugs Nivolumab (Primary) ; Fluorouracil; Folinic acid; Oxaliplatin
  • Indications Adenocarcinoma; Gastric cancer; Oesophageal cancer
  • Focus Therapeutic Use

Most Recent Events

  • 24 Jun 2025 Planned End Date changed from 1 Apr 2026 to 1 Jun 2026.
  • 04 Jun 2024 Results (n=73; from 7/11/2019 to 4/13/2023) assessing the short course chemotherapy (FOLFOX + nivolumab (Nivo) followed by maintenance Nivo +/- radiation (RT)) and the potential of radiation in improving the efficacy of checkpoint inhibition in the first line treatment of metastatic or unresectable gastroesophageal adenocarcinoma, presented at the 60th Annual Meeting of the American Society of Clinical Oncology.
  • 16 Jan 2024 Planned End Date changed from 1 Jan 2026 to 1 Apr 2026.

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