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A Phase I, Open-label, Multicentre, Dose Escalation Study to Assess Safety, Tolerability and Pharmacokinetics of Oral CPL304110, in Adult Subjects With Advanced Solid Malignancies

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Trial Profile

A Phase I, Open-label, Multicentre, Dose Escalation Study to Assess Safety, Tolerability and Pharmacokinetics of Oral CPL304110, in Adult Subjects With Advanced Solid Malignancies

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 12 Feb 2024

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At a glance

  • Drugs CLP 304110 (Primary)
  • Indications Basal cell cancer; Bladder cancer; Cholangiocarcinoma; Endometrial cancer; Gastric cancer; Lung cancer; Non-small cell lung cancer; Sarcoma; Solid tumours; Squamous cell cancer
  • Focus Adverse reactions
  • Sponsors Celon Pharma

    • Most Recent Events

    • 06 Feb 2024 Planned End Date changed from 1 Dec 2023 to 1 Jun 2024.
    • 06 Feb 2024 Planned primary completion date changed from 1 Dec 2023 to 1 Jun 2024.
    • 08 Mar 2023 Preliminary results of phase IA (n=21) assessing the safety, tolerability, and determination of the recommended phase II dose, the dose-response relationship for efficacy, and pharmacokinetics of CPL304110 in patients with FGFR-deregulated advanced solid malignancies, presented at the 21st International Congress on Targeted Anticancer Therapies.

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