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A Phase 1 Open-Label Study Evaluating the Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination With Ruxolitinib in Myeloproliferative Neoplasm Subjects

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Trial Profile

A Phase 1 Open-Label Study Evaluating the Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination With Ruxolitinib in Myeloproliferative Neoplasm Subjects

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 20 Feb 2025

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At a glance

  • Drugs Celecoxib (Primary) ; Navitoclax (Primary) ; Ruxolitinib (Primary)
  • Indications Essential thrombocythaemia; Myelofibrosis; Polycythaemia vera
  • Focus Adverse reactions; Pharmacokinetics
  • Sponsors AbbVie

Most Recent Events

  • 14 Feb 2025 Planned End Date changed from 29 Jan 2025 to 31 Dec 2026.
  • 14 Feb 2025 Planned primary completion date changed from 29 Jan 2025 to 31 Dec 2026.
  • 17 Jun 2024 Planned End Date changed from 8 Sep 2024 to 29 Jan 2025.

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