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A Phase II, Multicenter, Randomized, Open Label Two Arm Study Evaluating the Effect of Crizanlizumab + Standard of Care and Standard of Care Alone on Renal Function in Sickle Cell Disease Patients ≥ 16 Years With Chronic Kidney Disease Due to Sickle Cell Nephropathy (STEADFAST)

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Trial Profile

A Phase II, Multicenter, Randomized, Open Label Two Arm Study Evaluating the Effect of Crizanlizumab + Standard of Care and Standard of Care Alone on Renal Function in Sickle Cell Disease Patients ≥ 16 Years With Chronic Kidney Disease Due to Sickle Cell Nephropathy (STEADFAST)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 11 Jun 2024

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At a glance

  • Drugs Crizanlizumab (Primary) ; ACE inhibitors; Angiotensin receptor antagonists; Hydroxycarbamide
  • Indications Sickle cell anaemia
  • Focus Pharmacodynamics
  • Acronyms STEADFAST
  • Sponsors Novartis; Novartis Pharmaceuticals
  • Most Recent Events

    • 08 Mar 2024 This trial has been discontinued in Italy, according to European Clinical Trials Database record.
    • 22 May 2023 Status changed from active, no longer recruiting to completed.
    • 18 May 2023 This trial has been completed in Ireland (Date of the global end of the trial: 20- Mar 2023).

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