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A randomized, double-blind, parallel-group, multicenter study to assess efficacy, safety, and tolerability of oral tropifexor (LJN452) & licogliflozin (LIK066) combination therapy, compared to each monotherapy, compared with placebo for treatment of adult participants with nonalcoholic steatohepatitis (NASH) and liver fibrosis (ELIVATE)

Trial Profile

A randomized, double-blind, parallel-group, multicenter study to assess efficacy, safety, and tolerability of oral tropifexor (LJN452) & licogliflozin (LIK066) combination therapy, compared to each monotherapy, compared with placebo for treatment of adult participants with nonalcoholic steatohepatitis (NASH) and liver fibrosis (ELIVATE)

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 31 Jan 2025

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At a glance

  • Drugs Licogliflozin (Primary) ; Tropifexor (Primary)
  • Indications Hepatic fibrosis; Non-alcoholic steatohepatitis
  • Focus Therapeutic Use
  • Acronyms ELIVATE
  • Sponsors Novartis; Novartis Healthcare; Novartis Pharmaceuticals

Most Recent Events

  • 07 Dec 2023 Status changed from completed to discontinued.
  • 05 Jul 2023 Status changed from recruiting to completed.
  • 23 Nov 2022 This trial has been completed in Belgium, according to European Clinical Trials Database record.

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