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An Open-label, Adaptive Design Study in Patients With Amyotrophic Lateral Sclerosis (ALS) to Characterize Safety, Tolerability and Brain Microglia Response, as Measured by TSPO Binding, Following Multiple Doses of BLZ945 Using Positron Emission Tomography (PET) With the Radioligand [11C]-PBR28

Trial Profile

An Open-label, Adaptive Design Study in Patients With Amyotrophic Lateral Sclerosis (ALS) to Characterize Safety, Tolerability and Brain Microglia Response, as Measured by TSPO Binding, Following Multiple Doses of BLZ945 Using Positron Emission Tomography (PET) With the Radioligand [11C]-PBR28

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 29 Jul 2024

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At a glance

  • Drugs Sotuletinib (Primary)
  • Indications Amyotrophic lateral sclerosis
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors Novartis; Novartis Pharmaceuticals

Most Recent Events

  • 26 Jul 2024 Status changed from recruiting to discontinued after assessment of potential benefit-risk from available data .
  • 20 May 2024 Status changed from active, no longer recruiting to recruiting.
  • 26 Apr 2024 This trial has been discontinued in Sweden (Global end date: 26 Mar 2024).

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