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A Phase 1a/1b Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PY159 as a Single Agent and In Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

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Trial Profile

A Phase 1a/1b Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PY159 as a Single Agent and In Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 14 Jan 2025

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At a glance

  • Drugs Pembrolizumab (Primary) ; PY 159 (Primary)
  • Indications Adenocarcinoma; Advanced breast cancer; Carcinoma; Cervical cancer; Colorectal cancer; Endometrial cancer; Gastric cancer; Gynaecological cancer; Head and neck cancer; HER2 negative breast cancer; Lung cancer; Non-small cell lung cancer; Oesophageal cancer; Ovarian cancer; Pancreatic cancer; Salivary gland cancer; Solid tumours; Squamous cell cancer; Thyroid cancer; Triple negative breast cancer; Uterine cancer; Vulvovaginal cancer
  • Focus Adverse reactions; First in man; Pharmacokinetics
  • Sponsors Pionyr Immunotherapeutics

Most Recent Events

  • 08 Jan 2025 Status changed to completed, according to Foundery Immune Studio media release.
  • 20 Mar 2024 Status changed from active, no longer recruiting to discontinued.
  • 28 Jun 2023 Planned End Date changed from 7 Apr 2023 to 1 Dec 2025.

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