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An Open-label Phase I/IIa Study to Evaluate the Safety and Efficacy of CCS1477 as Monotherapy and in Combination in Patients With Advanced Haematological Malignancies

Trial Profile

An Open-label Phase I/IIa Study to Evaluate the Safety and Efficacy of CCS1477 as Monotherapy and in Combination in Patients With Advanced Haematological Malignancies

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 13 Jan 2026

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At a glance

  • Drugs Dexamethasone (Primary) ; Inobrodib (Primary) ; Pomalidomide (Primary) ; Azacitidine; Elranatamab; Teclistamab; Venetoclax
  • Indications Acute myeloid leukaemia; Acute promyelocytic leukaemia; Multiple myeloma; Myelodysplastic syndromes; Non-Hodgkin's lymphoma; Peripheral T-cell lymphoma; Richter's syndrome; T-cell lymphoma
  • Focus Adverse reactions; First in man
  • Sponsors CellCentric

Most Recent Events

  • 07 Dec 2025 According to a CellCentric media release, new data from the dose-optimization cohorts of phase 2 clinical trial of inobrodib in combination with pomalidomide and dexamethasone in heavily pretreated patients with relapsed/refractory multiple myeloma (RRMM) were presented during a poster session at the American Society of Hematology (ASH) Annual Meeting.
  • 07 Dec 2025 Results presented in a CellCentric Media release
  • 03 Nov 2025 According to CellCentric Media release, additional arms on this trial investigating inobrodib in combination with elranatamab and teclistamab are currently ongoing and enrolling.

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