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An Open-label Phase I/IIa Study to Evaluate the Safety and Efficacy of CCS1477 as Monotherapy and in Combination in Patients With Advanced Haematological Malignancies

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Trial Profile

An Open-label Phase I/IIa Study to Evaluate the Safety and Efficacy of CCS1477 as Monotherapy and in Combination in Patients With Advanced Haematological Malignancies

Status: Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 04 Dec 2025

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At a glance

  • Drugs Dexamethasone (Primary) ; Inobrodib (Primary) ; Pomalidomide (Primary) ; Azacitidine; Elranatamab; Teclistamab; Venetoclax
  • Indications Acute myeloid leukaemia; Acute promyelocytic leukaemia; Multiple myeloma; Myelodysplastic syndromes; Non-Hodgkin's lymphoma; Peripheral T-cell lymphoma; Richter's syndrome; T-cell lymphoma
  • Focus Adverse reactions; First in man
  • Sponsors CellCentric

Most Recent Events

  • 03 Nov 2025 According to CellCentric Media release, additional arms on this trial investigating inobrodib in combination with elranatamab and teclistamab are currently ongoing and enrolling.
  • 03 Nov 2025 According to CellCentric Media release, data from the trial will be presented at the 67th Annual American Society of Hematology (ASH) Meeting and Exposition, taking place December 6-9 in Orlando, Florida.
  • 09 Sep 2025 According to CellCentric Media release, the company is looking forward to sharing clinical data later this year.

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