Trial Profile

Randomised Phase 2 Trial Testing the Addition of Upfront Stereotactic Radiosurgery to Binimetinib Encorafenib Pembrolizumab Compared to Binimetinib Encorafenib Pembrolizumab Alone in BRAFV600 Mutation-positive Melanoma With Brain Metastasis

Status: Active, no longer recruiting

Phase of Trial: Phase II

Latest Information Update: 12 Jun 2026

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At a glance

Drugs Binimetinib (Primary) ; Encorafenib (Primary) ; Pembrolizumab (Primary)
Indications Brain metastases; Malignant melanoma
Focus Therapeutic Use
Acronyms BECOME-MB
Sponsors UNICANCER

05 Jun 2026 Planned End Date changed from 27 Mar 2026 to 27 Mar 2027.
25 Mar 2026 Planned End Date changed from 15 Apr 2029 to 27 Mar 2026.
25 Mar 2026 Planned primary completion date changed from 15 Apr 2025 to 27 Mar 2026.

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