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Randomised Phase 2 Trial Testing the Addition of Upfront Stereotactic Radiosurgery to Binimetinib Encorafenib Pembrolizumab Compared to Binimetinib Encorafenib Pembrolizumab Alone in BRAFV600 Mutation-positive Melanoma With Brain Metastasis

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Randomised Phase 2 Trial Testing the Addition of Upfront Stereotactic Radiosurgery to Binimetinib Encorafenib Pembrolizumab Compared to Binimetinib Encorafenib Pembrolizumab Alone in BRAFV600 Mutation-positive Melanoma With Brain Metastasis

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 02 Oct 2024

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At a glance

  • Drugs Binimetinib (Primary) ; Encorafenib (Primary) ; Pembrolizumab (Primary)
  • Indications Brain metastases; Malignant melanoma
  • Focus Therapeutic Use
  • Acronyms BECOME-MB
  • Sponsors UNICANCER

    • Most Recent Events

    • 31 May 2024 Status changed from recruiting to active, no longer recruiting.
    • 24 Oct 2023 According to Trial design presented at the 48th European Society for Medical Oncology Congress, an amendment to allow previous treatment with anti-PD-1 is ongoing.
    • 24 Oct 2023 Trial design presented at the 48th European Society for Medical Oncology Congress

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