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Randomized, Placebo-Controlled, Double-Masked Study of the Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) in Subjects With Dim Light Vision Disturbances

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Trial Profile

Randomized, Placebo-Controlled, Double-Masked Study of the Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) in Subjects With Dim Light Vision Disturbances

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 07 Sep 2025

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At a glance

  • Drugs Phentolamine (Primary)
  • Indications Nyctalopia; Vision disorders
  • Focus Registrational; Therapeutic Use
  • Acronyms LYNX-1
  • Sponsors Ocuphire Pharma

Most Recent Events

  • 21 Mar 2025 According to an Opus Genetics media release, the company announced that a presentation featuring the LYNX-1 Phase 3 study of Phentolamine Ophthalmic Solution 0.75% in patients with dim light disturbances will be delivered this week at World Cornea Congress IX, taking place March 20-22, 2025 in Washington, D.C.
  • 21 Mar 2025 Results presented in the Opus Genetics media release.
  • 21 Mar 2025 Primary endpoint(Percent of Subjects With 3 Lines mLCVA Improvement in Study Eye) has been met.

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