Trial Profile

An Open-label Phase 1/1b Study to Evaluate the Safety and Pharmacokinetics of JNJ-73841937 (Lazertinib), a Third Generation EGFR-TKI, as Monotherapy or in Combinations With JNJ-61186372, a Human Bispecific EGFR and cMet Antibody in Participants With Advanced Non-Small Cell Lung Cancer

Status: Active, no longer recruiting

Phase of Trial: Phase I

Latest Information Update: 30 Apr 2025

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At a glance

Drugs Amivantamab (Primary) ; Carboplatin (Primary) ; Lazertinib (Primary) ; Pemetrexed (Primary)
Indications Non-small cell lung cancer
Focus Adverse reactions; Therapeutic Use
Acronyms CHRYSALIS-2
Sponsors Janssen Pharmaceutical KK; Janssen Research & Development

20 Mar 2025 According to Johnson and Johnson media release, company will present data from this study in a poster presentation at the 2025 European Lung Cancer Congress (ELCC).
28 Feb 2025 Planned primary completion date changed from 3 Feb 2025 to 3 Jun 2026.
24 Oct 2024 Status changed from recruiting to active, no longer recruiting.

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