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An Open-label, Multi-drug, Multi-center Phase II Combination Study of AZD4635 in Patients With Prostate Cancer.

Trial Profile

An Open-label, Multi-drug, Multi-center Phase II Combination Study of AZD4635 in Patients With Prostate Cancer.

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 21 Mar 2024

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At a glance

  • Drugs Durvalumab (Primary) ; Imaradenant (Primary) ; Oleclumab (Primary)
  • Indications Prostate cancer
  • Focus Therapeutic Use
  • Sponsors AstraZeneca
  • Most Recent Events

    • 02 Mar 2024 Results evaluating the A2AR antagonist AZD4635 in combination with durvalumab or oleclumab in patients with metastatic castration-resistant prostate cancer, published in the Cancer Immunology Immunotherapy
    • 29 May 2023 Status changed from active, no longer recruiting to completed.
    • 18 Feb 2023 Interim results from Arm B (Arm A to be reported elsewhere) assessing safety and efficacy (n=30; As of August 10, 2021) of AZD4635 in combination with durvalumab (Arm A) or with durvalumab + cabazitaxel (Arm B) in patients with metastatic castrate-resistant prostate cancer, presented at the 2023 Genitourinary Cancers Symposium.

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