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A Phase 3, Randomized, Observer-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Healthy Participants 16 to 40 Years of Age

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Trial Profile

A Phase 3, Randomized, Observer-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Healthy Participants 16 to 40 Years of Age

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 21 Jan 2025

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At a glance

  • Drugs MRNA-1647 (Primary)
  • Indications Cytomegalovirus infections
  • Focus Adverse reactions; Pharmacodynamics; Registrational
  • Acronyms CMVictory
  • Sponsors Moderna Therapeutics

Most Recent Events

  • 13 Jan 2025 According to a Moderna Therapeutics media release, The Company anticipates final efficacy data from the study in 2025.
  • 24 Dec 2024 Planned End Date changed from 6 Apr 2026 to 6 Apr 2028.
  • 27 Mar 2024 According to a Moderna Therapeutics media release, to date, 50 primary infection cases have accrued and are undergoing confirmation. The first interim analysis for the evaluation of vaccine efficacy, which will be triggered when both 81 confirmed per-protocol cases and 12 median months of safety follow-up have occurred, is expected as early as the end of 2024.

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