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Phase 1/2a, First-in-human, Open-label, Dose-escalation Trial With Expansion Cohorts to Evaluate Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of BNT411 as a Monotherapy in Patients With Solid Tumors and in Combination With Atezolizumab, Carboplatin and Etoposide in Patients With Chemotherapy-naïve Extensive-stage Small Cell Lung Cancer (ES-SCLC)

Trial Profile

Phase 1/2a, First-in-human, Open-label, Dose-escalation Trial With Expansion Cohorts to Evaluate Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of BNT411 as a Monotherapy in Patients With Solid Tumors and in Combination With Atezolizumab, Carboplatin and Etoposide in Patients With Chemotherapy-naïve Extensive-stage Small Cell Lung Cancer (ES-SCLC)

Status: Discontinued
Phase of Trial: Phase I/II

Latest Information Update: 21 Mar 2025

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At a glance

  • Drugs BNT 411 (Primary) ; Atezolizumab; Carboplatin; Etoposide
  • Indications Bladder cancer; Colorectal cancer; Non-small cell lung cancer; Pancreatic cancer; Small cell lung cancer; Solid tumours
  • Focus Adverse reactions; First in man
  • Sponsors BioNTech

Most Recent Events

  • 02 Aug 2024 Status changed from active, no longer recruiting to discontinued.
  • 26 Apr 2024 This trial has been discontinued in Spain according to European Clinical Trials Database record
  • 04 Apr 2024 This trial has been suspended in Germany.

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