Trial Profile

Phase 1/2a, First-in-human, Open-label, Dose-escalation Trial With Expansion Cohorts to Evaluate Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of BNT411 as a Monotherapy in Patients With Solid Tumors and in Combination With Atezolizumab, Carboplatin and Etoposide in Patients With Chemotherapy-naïve Extensive-stage Small Cell Lung Cancer (ES-SCLC)

Status: Discontinued

Phase of Trial: Phase I/II

Latest Information Update: 21 Mar 2025

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At a glance

Drugs BNT 411 (Primary) ; Atezolizumab; Carboplatin; Etoposide
Indications Bladder cancer; Colorectal cancer; Non-small cell lung cancer; Pancreatic cancer; Small cell lung cancer; Solid tumours
Focus Adverse reactions; First in man
Sponsors BioNTech

02 Aug 2024 Status changed from active, no longer recruiting to discontinued.
26 Apr 2024 This trial has been discontinued in Spain according to European Clinical Trials Database record
04 Apr 2024 This trial has been suspended in Germany.

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