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PRESERVE 1: A Phase 3 Randomized, Double-blind Trial of Trilaciclib Versus Placebo in Patients Receiving FOLFOXIRI/Bevacizumab for Metastatic Colorectal Cancer

Trial Profile

PRESERVE 1: A Phase 3 Randomized, Double-blind Trial of Trilaciclib Versus Placebo in Patients Receiving FOLFOXIRI/Bevacizumab for Metastatic Colorectal Cancer

Status: Discontinued
Phase of Trial: Phase III

Latest Information Update: 02 Dec 2024

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At a glance

  • Drugs Trilaciclib (Primary) ; Bevacizumab; Fluorouracil; Folinic acid; Irinotecan; Oxaliplatin
  • Indications Adenocarcinoma; Colon cancer; Colorectal cancer; Myelosuppression; Rectal cancer
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms PRESERVE 1
  • Sponsors G1 Therapeutics
  • Most Recent Events

    • 04 Jul 2023 This trial has been completed in Poland, according to the European Clinical Trials Database record.
    • 13 Feb 2023 According to a G1 Therapeutics media release, company will host a webcast and conference call at 8:30 am ET today to discuss PRESERVE 1 and Company's ongoing commercial and clinical programs.
    • 13 Feb 2023 According to a G1 Therapeutics media release, company announced topline data and co-primary endpoints data related to severe neutropenia with statistical significance data of this trial.

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