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A Phase III, Multicenter, Randomized, Open-Label Study of Atezolizumab (Anti-PD-L1 Antibody) Plus Bevacizumab Versus Active Surveillance as Adjuvant Therapy in Patients With Hepatocellular Carcinoma at High Risk of Recurrence After Surgical Resection or Ablation

Trial Profile

A Phase III, Multicenter, Randomized, Open-Label Study of Atezolizumab (Anti-PD-L1 Antibody) Plus Bevacizumab Versus Active Surveillance as Adjuvant Therapy in Patients With Hepatocellular Carcinoma at High Risk of Recurrence After Surgical Resection or Ablation

Status: Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 12 Jun 2025

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At a glance

  • Drugs Atezolizumab (Primary) ; Bevacizumab (Primary)
  • Indications Liver cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms IMbrave050
  • Sponsors Roche

Most Recent Events

  • 27 Oct 2023 Results assessing the efficacy of adjuvant atezolizumab plus bevacizumab versus active surveillance in patients with high-risk hepatocellular carcinomapublished in the Internet Document
  • 24 Jun 2023 Results (n=334) assessing safety and patient-reported outcomes from IMbrave050 presented at the European Association for the Study of the Liver Congress 2023
  • 06 Jun 2023 Results of PRO outcomes presented at the 59th Annual Meeting of the American Society of Clinical Oncology

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