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A Phase II Open-Label Study of UM171-Expanded Cord Blood Transplantation in Patients With High and Very High Risk Acute Leukemia/Myelodysplasia

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Trial Profile

A Phase II Open-Label Study of UM171-Expanded Cord Blood Transplantation in Patients With High and Very High Risk Acute Leukemia/Myelodysplasia

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 06 Feb 2025

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At a glance

  • Drugs Dorocubicel-ExCellThera (Primary) ; Cyclophosphamide; Fludarabine; MMF; Tacrolimus; Thiotepa
  • Indications Acute myeloid leukaemia; Chronic myeloid leukaemia; Graft-versus-host disease; Myelodysplastic syndromes; Precursor cell lymphoblastic leukaemia-lymphoma
  • Focus Adverse reactions; Therapeutic Use
  • Sponsors ExCellThera

    • Most Recent Events

    • 10 Dec 2024 Results examining the outcome of patients with poor outcome TP53 or EVI1 anomalies who were transplanted with a single UM171 CBT during the course of phase I-II(n=1) and phase II(n=9) trial, presented at the 66th American Society of Hematology Annual Meeting and Exposition
    • 15 Feb 2024 Planned End Date changed from 1 Nov 2025 to 1 Feb 2026.
    • 15 Feb 2024 Planned primary completion date changed from 1 Nov 2023 to 1 Feb 2026.

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