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An Open-label, 3-period Fixed-sequence Study in Healthy Subjects to Assess the Pharmacokinetics of Savolitinib When Administered Alone and in Combination With Rifampicin

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Trial Profile

An Open-label, 3-period Fixed-sequence Study in Healthy Subjects to Assess the Pharmacokinetics of Savolitinib When Administered Alone and in Combination With Rifampicin

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 17 Sep 2021

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At a glance

  • Drugs Savolitinib (Primary) ; Rifampicin
  • Indications CNS cancer; Colorectal cancer; Gastric cancer; Lung cancer; Non-small cell lung cancer; Prostate cancer; Renal cell carcinoma; Solid tumours
  • Focus Pharmacokinetics
  • Sponsors AstraZeneca

Most Recent Events

  • 28 Jul 2021 Results assessing the effect of rifampicin, itraconazole and famotidine on savolitinib PK, and the effect of savolitinib on midazolam exposure from four studies (NCT04118842, NCT04121910, NCT04179071,NCT04187456) published in the British Journal of Clinical Pharmacology
  • 17 Mar 2021 Results of pooled analysis assessing pharmacokinetics from two phase I studies presented at the 122nd Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics
  • 02 Apr 2020 Status changed from active, no longer recruiting to completed.

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